Advanced Management Strategies in Severe Asthma and COPD (MC)-Unmet Need in Asthma Kraft

Unmet Need in Asthma Kraft

Pdf Summary

The document "Advances in Severe Asthma: Update 2024" by Monica Kraft, MD, highlights recent advancements and ongoing challenges in the management of severe asthma. Dr. Kraft, with extensive affiliations with the Icahn School of Medicine at Mount Sinai, has disclosed financial relationships with various pharmaceutical companies and research organizations. <br /><br />The document discusses the heterogeneity of asthma, noting that its severity, progression, and response to treatment are influenced by numerous genetic and environmental factors. It outlines the distinction between T2-high and T2-low asthma, emphasizing how different inflammatory pathways, particularly those involving molecules like IL-4, IL-13, and IL-6, influence these phenotypes. The document stresses the need for deeper understanding and improved therapeutic strategies, especially for non-T2 asthma, which currently lacks comprehensive treatment options.<br /><br />Potential therapeutic advancements are explored, including novel pharmacological treatments in various stages of development, targeting specific asthma biomarkers or mechanisms. Some drugs in trials are targeting unique pathways like IL-17, IL-33, and TSLP, aiming to reduce inflammation and symptoms in patients with severe asthma.<br /><br />The paper also emphasizes the importance of small airway dysfunction in asthma management, indicating how it is often linked to more severe asthma phenotypes and can predict exacerbations. Techniques like impulse oscillometry and other physiological tests are detailed as valuable tools for assessing small airway function and asthma control.<br /><br />The document concludes by recognizing unmet needs in asthma care, such as the necessity for better phenotyping and personalized treatment approaches for severe asthma, particularly non-T2 types. In summary, while significant progress has been made, further research and development are crucial for achieving better diagnostic, monitoring, and treatment strategies in severe asthma.

Keywords

severe asthma

Monica Kraft

T2-high asthma

T2-low asthma

IL-4

IL-13

IL-17

IL-33

TSLP

small airway dysfunction