CHEST 2023 On Demand Pass-Asthma and Allergy

Video Transcription

Video Summary

The video transcript features four different presenters who discuss various topics related to asthma. Dr. Lori Mankey discusses the use of Dornes' Alpha therapy for neutrophilic asthma. Neutrophilic asthma is characterized by poor symptom control, chronic airflow obstruction, and corticosteroid insensitivity. Dornes' Alpha is a nebulized recombinant deoxyribonuclease that reduces the viscosity of sputum by cleaving extracellular DNA and neutrophilic extracellular traps. A pilot study investigated the safety and effects of Dornes' Alpha in neutrophilic asthma patients. While there were no significant changes in lung function or asthma control, the study revealed a positive perception among participants, especially those with higher BMI, of improved ease of sputum expectoration and thinning of sputum.<br /><br />Dr. Amjad Kanj presents on the association between the relative abundance of Clodosporium in sputum and asthma control. Clodosporium is a fungal genus commonly found both indoors and outdoors. The study found that Clodosporium was significantly more prevalent in the sputum of individuals with worse asthma control compared to those with better control. This suggests a potential link between Clodosporium abundance and poor asthma control, though further research is needed to establish causation.<br /><br />Dr. Linda Pham discusses a retrospective study on the trends of patients hospitalized for asthma exacerbations with and without concomitant eosinophilic esophagitis (EOE) in the United States. The study found that patients with both asthma and EOE presented earlier to the hospital compared to those with asthma alone or EOE alone. Additionally, females had a higher prevalence of asthma compared to males. The study highlights the need for further investigation into the relationship between different atopic diseases and their impact on hospitalization timing.<br /><br />Dr. Laura Huyu presents on the high burden of asthma acute care in Singapore over the next 20 years. The study projected an increase in asthma admission rates in Singapore, despite declining global trends. However, the asthma-related ED attendance rate is expected to decrease over time. The asthma mortality rate is expected to remain low. The findings highlight the importance of implementing effective asthma management strategies and shifting care from tertiary to primary settings to reduce avoidable admissions.

Meta Tag

Category Allergy and Airway

Session ID 4023

Speaker Amjad Kanj

Speaker Laura Huey Mien Lim

Speaker Meixuan Liu

Speaker Laurie Manka

Speaker Linda Pham

Track Allergy and Airway

Keywords

asthma

neutrophilic asthma

Dornes' Alpha therapy

sputum expectoration

Clodosporium

asthma control

hospitalization timing