CHEST 2023 On Demand Pass-Beyond Smoking: Identifying Those With Lung Cancer Risk

Video Transcription

Video Summary

This video discusses lung cancer in specific patient populations, including never smokers, immune dysregulated patients, those with chronic infections (such as HIV), lung transplant patients, and younger individuals. <br /><br />In the first part of the video, the focus is on lung cancer in never smokers, which accounts for a significant proportion of lung cancer cases. The video highlights the biology of lung cancer in never smokers, including the presence of driver mutations that can be targeted by drugs. It also mentions that never smokers have a lower tumor mutational burden, making them less likely to respond to immunotherapy. <br /><br />The second part of the video discusses lung cancer in immune dysregulated patients, such as those with connective tissue diseases like rheumatoid arthritis and lupus. These patients have an increased risk of lung cancer, although the exact mechanisms are not fully understood. <br /><br />The third part of the video explores the correlation between lung cancer and chronic infections, specifically HIV. Individuals with HIV and low CD4 counts have a higher risk of developing lung cancer. The timing of lung cancer diagnosis in lung transplant patients is also discussed, typically occurring around four years after transplantation. <br /><br />Additionally, the video touches on the incidence of lung cancer in younger individuals, including those under 40 years of age. Various risk factors contribute to the development of lung cancer in this group, such as family history, environmental exposures, passive smoking, and occupational exposure. <br /><br />Overall, the video highlights the need for further research and understanding of lung cancer in these specific patient populations, as well as the potential benefits of incorporating additional risk factors into lung cancer screening guidelines and personalized screening approaches.

Meta Tag

Category Lung Cancer

Session ID 1149

Speaker Vivek Murthy

Speaker Viswam Nair

Speaker Catherine Sears

Speaker Robert Smyth

Track Lung Cancer

Keywords

lung cancer

specific patient populations

never smokers

immune dysregulated patients

chronic infections

HIV

lung transplant patients

younger individuals

driver mutations

tumor mutational burden

immunotherapy