CHEST 2023 On Demand Pass-Novel Insights into Diagnosis of PH

Video Transcription

Video Summary

The study investigated the relationship between diffusing capacity for carbon monoxide (DLCO) and patient characteristics and outcomes in patients with pulmonary vascular disease. The study used data from the PVD-Omics study, which aims to provide an updated pulmonary hypertension classification. The results showed that low DLCO was common in groups 1-3 pulmonary hypertension and was associated with markers of disease severity such as older age, male gender, smoking history, and worse functional parameters. In group 1 patients, low DLCO was also associated with certain etiologies such as pulmonary veno-occlusive disease and connective tissue disease-associated pulmonary hypertension. The study found that every 10% reduction in DLCO was associated with a 33% increase in the hazard of death or transplant. Patients with low DLCO were also less likely to be on pulmonary hypertension specific therapy, including prostanoids, despite having a worse prognosis. Overall, the study highlights the importance of measuring DLCO in patients with pulmonary hypertension as it is associated with disease severity and prognosis.

Meta Tag

Category Pulmonary Vascular Disease

Session ID 4034

Speaker Michele Dalto

Speaker Daniel Lachant

Speaker Niala Moallem

Speaker Divya Padmanabhan Menon

Speaker Laura Saldivar

Speaker Francisco Soto

Track Pulmonary Vascular Disease

Keywords

DLCO

patient characteristics

outcomes

pulmonary vascular disease

disease severity

functional parameters

etiologies

prognosis