CHEST COPD Immersion June 2025-Dx considerations Workshop

Dx considerations Workshop_Bourbeau

Pdf Summary

The workshop presented by Dr. J. Bourbeau aims to explore the diagnosis of four key respiratory conditions: Asthma, Chronic Obstructive Pulmonary Disease (COPD), Asthma-COPD Overlap (ACO), and Preserved Ratio Impaired Spirometry (PRISm). The discussion highlights the importance of precise diagnostic methods, including spirometry and advanced biomarkers, to better manage these conditions.<br /><br />The diagnosis of asthma involves various tests designed to measure airflow variability and other respiratory aspects. Recent studies reveal that asthma diagnoses may sometimes be incorrect, as demonstrated by a multi-center study where asthma was ruled out in 33% of participants previously diagnosed. Diagnosis requires careful evaluation of symptoms and confirmatory tests such as bronchial challenges, which are influenced by factors like viral infections or exercise.<br /><br />COPD diagnosis similarly employs spirometry, which robustly validates obstructive airway conditions. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2025 report emphasizes the use of spirometric values to improve clinical consistency. Biomarkers, such as elevated eosinophils, can aid in tailoring therapeutic interventions, particularly the use of inhaled corticosteroids (ICS).<br /><br />The workshop also delves into characterizing COPD phenotypes and subtypes via imaging advancements, specifically CT scans, which reveal complications like emphysema or mucus plugs associated with increased mortality. Distinct lung phenotypes and biomarkers steer precision medical strategies in managing COPD's heterogeneity.<br /><br />PRISm, or Preserved Ratio Impaired Spirometry, presents diagnostic challenges and associations with increased morbidity and mortality, demanding attention for early and targeted treatment strategies. <br /><br />Overall, this session underscores the evolving landscape of respiratory diagnostics, aiming to enhance personalized treatment approaches for asthma, COPD, ACO, and PRISm, factoring in the latest research, diagnostic tools, and biomarkers.

Keywords

respiratory conditions

asthma

COPD

Chronic Obstructive Pulmonary Disease

Asthma-COPD Overlap

PRISm

spirometry

biomarkers

diagnostic methods

personalized treatment

lung phenotypes