CHEST Immersion Severe Asthma May 29-30, 2024-Severe Asthma

Severe Asthma

Pdf Summary

The document discusses severe and uncontrolled asthma, emphasizing the importance of accurate diagnosis, evaluation, and treatment. It stresses the heterogeneity of asthma as a disease with variable symptoms and airflow limitations. The burden of severe asthma is highlighted, with substantial costs and implications for healthcare systems. The document outlines the factors contributing to uncontrolled asthma, including environmental exposures, comorbid conditions, and medication adherence issues. It addresses the need for thorough patient history and assessment of triggers, therapy adherence, and comorbidities. Risk factors for severe asthma are detailed, including genetic, environmental, and occupational influences. The text also introduces biologic treatments for severe asthma targeting specific pathways such as IgE, IL-5, IL-4R, and TSLP. It stresses the importance of personalized asthma management through phenotyping and the use of available biomarkers. The document concludes with a call for further research to address unanswered questions regarding treatment efficacy, duration, and switching strategies.

Keywords

severe asthma

uncontrolled asthma

accurate diagnosis

treatment evaluation

asthma heterogeneity

healthcare costs

environmental exposures

medication adherence

patient history assessment

biologic treatments