Contemporary Questions in Pulmonary and Critical Care Infections-Resistant Superbugs Can We Curb the CRE Metersky

Resistant Superbugs Can We Curb the CRE Metersky

Pdf Summary

The article "Resistant Superbugs: Can We Curb the CRE?" by Mark L. Metersky, MD, focuses on the challenges of managing infections caused by multi-drug resistant (MDR) Gram-negative bacteria, particularly Carbapenem-resistant Enterobacteriaceae (CRE). These infections are associated with increased mortality because they often lead to inappropriate initial antibiotic therapy and delay the administration of appropriate treatment. <br /><br />Numerous studies have highlighted the need for rapid diagnostic tools to identify antibiotic-resistant bacteria promptly, as this could lead to more effective and targeted treatments. However, while rapid diagnostics can improve the frequency of appropriate initial antibiotic therapy, they must be part of a broader antibiotic stewardship program to effectively reduce infection rates.<br /><br />The development of antibiotic stewardship programs has been proven to be one of the most effective strategies for reducing the prevalence of MDR infections, including those caused by ESBL and carbapenemase-producing organisms. These programs ensure the judicious use of antibiotics, potentially curbing the emergence and spread of resistance.<br /><br />Emerging therapies, such as phage therapy and monoclonal antibodies, are being explored to tackle multi-drug resistant infections. Phage therapy, involving bacteriophages that specifically target bacterial pathogens, is under investigation in clinical trials for its effectiveness and safety. Additionally, vaccines against specific pathogens like Pseudomonas aeruginosa are being developed, though none have yet reached advanced stages of clinical trials.<br /><br />In summary, combating MDR Gram-negative pathogens necessitates reducing antibiotic usage through stewardship programs and the development of novel therapeutic approaches. These efforts aim to mitigate the impact of antibiotic resistance and prevent the occurrence of difficult-to-treat infections.

Keywords

superbugs

multi-drug resistant

Carbapenem-resistant Enterobacteriaceae

antibiotic resistance

rapid diagnostics

antibiotic stewardship

phage therapy

monoclonal antibodies

Gram-negative bacteria

novel therapies