Sleep Medicine: Cutting Edge Insights and Innovations Post Graduate Course-Trends in Diagnostics and Therapy for OSA PATIL

Trends in Diagnostics and Therapy for OSA PATIL

Pdf Summary

The session "Obstructive Sleep Apnea Disorder: Trends in Diagnostics and Treatments," presented by Dr. Susheel P. Patil, focused on the latest technologies and therapies for diagnosing and treating Obstructive Sleep Apnea (OSA). Key objectives included reviewing emerging technologies for OSA diagnosis, understanding the technology behind diagnostic devices, and exploring new non-Positive Airway Pressure (PAP) treatments.<br /><br />### Diagnostic Innovations:<br />- **Technology**: Several FDA-cleared devices, including Class II devices, are improving OSA diagnostics through screening capabilities such as Hypoglossal nerve stimulation, and PPG (Photoplethysmography) versus non-PPG wearable technologies like body movement detectors.<br />- **Wearables**: New consumer devices like Samsung's Galaxy Watch and the upcoming Apple Watch are being authorized for sleep apnea screening.<br /> <br />### Treatment Advances:<br />- **Non-PAP Therapies**: Recent therapies involve hypoglossal nerve stimulation and various negative pressure methods, including intra-oral and external negative pressure. Medications like Atomoxetine/Reboxybutynin (AD-109) and GLP-1 agonists such as Tirzepatide also show promise.<br />- **Emerging Drug Therapies**: Trials indicated positive outcomes with new medications including Sulthiame and Atomoxetin/Oxybutynin.<br />  <br />### Challenges and Future Directions:<br />- **Challenges**: The session highlighted challenges such as diagnostic method precision, generalizability to diverse populations, and financial considerations including reimbursement issues.<br />- **Opportunities**: There are ongoing opportunities to improve OSA management by reducing diagnosis-to-treatment time, enabling more cost-effective solutions, and utilizing continuous patient monitoring.<br /><br />### Pathophysiological Insights:<br />- **OSA Endotyping**: The discussion emphasized different endotypes and the benefit of targeting treatments to specific patient profiles.<br /><br />Overall, the session underscored the importance of technological advancement and personalized medicine in improving OSA patient outcomes beyond traditional CPAP therapies.

Keywords

Obstructive Sleep Apnea

OSA diagnostics

Hypoglossal nerve stimulation

Photoplethysmography

Wearable technology

Non-PAP therapies

Atomoxetine/Reboxybutynin

GLP-1 agonists

OSA endotyping

Personalized medicine