TEST - Book of PDFs-01_Bourjeily Chronic lung disease and gynecologic and obstetric_CMS.pptx

01_Bourjeily Chronic lung disease and gynecologic and obstetric_CMS.pptx - 1

Pdf Summary

This document discusses the impact of cystic fibrosis (CF) on fertility in female patients and the risk of mortality in pulmonary hypertension (PH). In regards to CF, while up to 98% of men with CF are infertile, fertility in females with CF is less clear but still relevant. Issues in the reproductive system include distorted cervical mucus and altered bicarbonate secretion in the uterus, leading to difficulties in egg fertilization. Menarche and hormonal changes in girls with CF are delayed compared to their peers, and abnormalities in menstruation can occur. However, around 50% of women with CF are able to conceive.<br /><br />In terms of PH, a patient with idiopathic pulmonary hypertension is advised to consider permanent contraception due to the significant risks involved with pregnancy. The efficacy of various contraceptive methods in PH patients is discussed, with some options being more acceptable than others due to the risk of failure or complications. Additionally, the safety of various PH drugs during pregnancy and lactation is evaluated, with some showing potential teratogenic effects or high toxicities in children.<br /><br />Overall, it is emphasized that patients with CF or PH should be educated about the risks and considerations related to fertility and pregnancy. The document also mentions a Women's Health Network Business Meeting that includes discussions on risk stratification models for sleep apnea, program development for CHEST 2017, and opportunities for involvement and input.

Keywords

cystic fibrosis

fertility

female patients

mortality

pulmonary hypertension

reproductive system

contraception

pregnancy risks

contraceptive methods

PH drugs