TEST - Book of PDFs-01_Ioachimescu_Pharmacol Rx of Smoking Ioachimescu 2016 CMS PC.pptx

01_Ioachimescu_Pharmacol Rx of Smoking Ioachimescu 2016 CMS PC.pptx

Pdf Summary

This document discusses the pharmacological therapy options for smoking cessation. It provides information on FDA-approved medications for smoking cessation, including nicotine replacement therapy (NRT) options such as patches, gum, lozenges, inhalers, nasal spray, and the prescription drug bupropion (Wellbutrin SR). It also covers the use of varenicline (Chantix), a partial agonist/antagonist of the α4β2 receptor, as a first-line therapy. <br /><br />The document mentions the dosing, side effects, and precautions associated with each medication. It also discusses second-line agents, including clonidine, nortriptyline, and cytisine, which are not FDA-approved but have shown efficacy in smoking cessation. <br /><br />Results from various studies comparing different medications for smoking cessation are presented. The document concludes that NRT, bupropion, and varenicline are all effective in improving the chances of quitting smoking with minimal risk of harm. NRT combinations are as effective as varenicline and more effective than single types of NRT. Cytisine is identified as a potential safe, effective, and affordable option. Nortriptyline is also found to improve the chances of quitting with little evidence of harm. The document emphasizes the need for continued monitoring of the safety of varenicline and suggests that further research on NRT versus placebo may not be necessary.

Keywords

pharmacological therapy

smoking cessation

FDA-approved medications

nicotine replacement therapy

bupropion

varenicline

dosing

side effects

efficacy

quitting smoking