Cystic Fibrosis Awareness: Structural and Functional Pulmonary MRI to Predict Pulmonary Exacerbations

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This podcast explores the use of structural and functional pulmonary MRI to predict pulmonary exacerbations in cystic fibrosis (CF), as outlined in the journal CHEST® study, Structural and Functional Pulmonary MRI to Predict Pulmonary Exacerbations in Cystic Fibrosis. Learn about the limitations of traditional monitoring tools such as FEV1; the role of ventilation defect percentage as a marker of regional lung dysfunction and future exacerbation risk; the differences between structural and functional MRI assessments; and the potential value of ultrashort echo time and Xenon-129 MRI in the era of CF transmembrane conductance regulator modulator therapy. This episode highlights how advanced imaging biomarkers may help identify early disease progression and support more personalized approaches to monitoring and long-term management in CF. 

This resource is available as part of the CHEST e-Learning Library subscription.

Content was developed in collaboration with CHEST subject matter experts who reviewed, edited, and revised it to ensure accuracy, integrity, and educational value. Artificial intelligence-assisted tools were used during the process, including audio generation.